Common name: Nicotinamide Riboside Hydrogen malate
Synonyms: Nicotinamide riboside malate, NRHM, NR Malate, 3-Carbamoyl-1-(β-D-ribofuranosyl)pyridinium 2-hydroxybutanedioate (2S) (1:1)
CAS NO.: 2415659-01-5
Molecular Formula: C15H20N2O10
Molecular Weight: 388.33
Structure:

Specification: 98%, 99%
Test method: HPLC
Appearance: off-white powder to white powder
Loss on drying: <2.0%
Total heavy metals: <10ppm
Total plate count: <1000cfu/g
Yeast&Mold: <100cfu/g
Packing: 5, 20KG/package
Storage: Store in cool and dry place and keep away from strong direct light and heat
Shelf Life: Two years when properly stored

Applications:

Dietary Supplements / Nutraceuticals: Utilized as an advanced, next-generation oral active ingredient in anti-aging capsules, tablets, and powder blends targeting cellular longevity, metabolic optimization, and sports performance.

Cosmetics & Personal Care:Incorporated into premium skincare formulations (serums, night creams) focused on chronobiology, mitigating oxidative stress, and repairing sleep-deprived skin ("overnight skin repair").

What is Nicotinamide Riboside Hydrogen malate?

Nicotinamide Riboside Hydrogen Malate (NRHM) is a novel structural salt form of Nicotinamide Riboside (NR), which is an efficient precursor to Nicotinamide Adenine Dinucleotide (NAD+). Traditional crystalline forms of NR, such as Nicotinamide Riboside Chloride, are highly hygroscopic and susceptible to heat and moisture degradation, severely challenging their shelf-life stability in final commercial formulations.

By chemically combining the nicotinamide riboside molecule with malic acid into a hydrogen malate crystal lattice, the stability against environmental moisture and light is vastly improved. This advanced counter-ion matching enhances physical handling during manufacturing, preserves raw bioactivity, and presents excellent oral absorption rates and water solubility compared to generic standalone NR alternatives.

Health Benefits of Nicotinamide Riboside Hydrogen malate

Highly Efficient NAD+ regulation:It serves as a direct pathway precursor to boost systemic and intracellular NAD+ pools, vital for maintaining cellular vitality as natural baseline levels decline with age.

Sirtuin Activation & Mitochondrial Fitness:By increasing NAD+ availability, it stimulates the upregulation of healthy-aging deacetylase proteins (SIRT1and SIRT3). This drives mitochondrial biogenesis via the PGC-1 alpha pathway, leading to more efficient oxidative metabolism and enhanced cellular ATP output.

Circadian Rhythm & Cellular Repair Synchronization: Supports the body’s natural biological clock regulation at a cellular level, assisting in DNA repair pathways and mitigating the metabolic abnormalities or skin fatigue associated with sleep deprivation or chronic stress.

Neuroprotective & Cognitive Support: Enhances brain cell energetic efficiency and neuroplasticity. Animal models show potential in suppressing metabolic and cognitive deterioration related to neurodegenerative pathways.

Metabolic and Hepatic Optimization: Protects tissues against high-fat diet-induced metabolic stressors, promotes glucose tolerance, and prevents unwanted lipid/fat deposition in hepatic tissues by accelerating fatty acid conversion into metabolic fuel.